Propranolol Event Planner
Visualize your dosing plan against your event schedule using peer-reviewed pharmacokinetic data
β οΈ MEDICAL DISCLAIMER
Click to Read & Continue β
βΆ
This tool is an EDUCATIONAL TOOL ONLY. Results are based on pharmacological models and general prescribing considerations, not individualized medical assessment.
Individual responses to propranolol vary significantly due to:
- Medical conditions and comorbidities
- Current medications and potential interactions
- Personal medical history
- Individual physiology and response patterns
β οΈ Timing Estimates: The optimized schedules shown are timing suggestions based on pharmacological models. They are pattern-based estimates that have NOT been validated in clinical trialsβthey represent alignment with typical prescribing considerations, not measured outcomes from patient studies. They do NOT predict effectiveness, safety, or appropriateness for your specific situation.
This tool is NOT a substitute for professional medical advice, diagnosis, or treatment.
Always consult your healthcare provider before:
- Starting any new medication
- Changing or stopping current medications
- Combining medications with other substances
If you experience concerning symptoms, contact your doctor immediately.
In no event will the creators nor related third parties be liable for any loss or damage arising from use of this educational tool.
Privacy Note: Your inputs are stored locally on your device for convenience. No data is transmitted to external servers. You can clear this data in your browser settings.
βΉοΈ Tool Classification: This is an educational wellness tool designed to help you understand your prescribed propranolol and prepare for conversations with your healthcare provider. It is not a medical device and has not been cleared or approved by the FDA. All results are for educational purposes only.
π Your Dosing Plan
Healthy liver. Standard first-pass metabolism.
𧬠Why isn't CYP2D6 status included?
Unlike some beta-blockers (e.g., metoprolol), propranolol's clearance is not significantly affected by CYP2D6 genetic variants. Research shows "no difference in oral clearance or elimination half-life" between CYP2D6 poor and extensive metabolizers (Sowinski 1997; FDA Inderal Label). This is because propranolol uses multiple metabolic pathways (CYP2D6, CYP1A2, CYP2C19, glucuronidation) that compensate for each other.
π About Liver Function: Most people have normal liver function. Only change this setting if you have been diagnosed with liver conditions (cirrhosis, hepatitis, etc.). When in doubt, keep defaults and consult your healthcare provider.
First-Time User: What to Expect
𧑠Educational Note: First-time users often experience the full bioavailability effect because their liver enzymes haven't adapted yet.
Why first-time response differs:
- No prior exposure: Your body hasn't yet adapted to propranolol metabolism
- Higher effective concentration: You may feel stronger effects from the same dose compared to regular users
- Individual variation is highest: Without prior experience, you can't predict your personal response
Recommended approach:
- Start with the lowest effective dose (typically 10mg)
- Take it on a low-stakes day to observe your response
- Wait 2-3 days before adjusting dose
- Monitor for side effects (dizziness, fatigue, cold extremities)
β οΈ Important: This tool shows population averages. Your individual bioavailability may differ significantly. Always follow your healthcare provider's guidance.
π Understanding Beta-Blockade Levels
π½οΈ How Food Changes Your Blockade Level
Taking propranolol with food increases bioavailability by 50-80% (Melander 1977, Walle 1981). This means the same dose produces significantly higher plasma concentrations β and therefore greater beta-blockade. Adjusting food timing is a practical way to shift where you fall on the effect spectrum without changing your prescribed dose.
π Understanding Blockade Percentage
Beta-blockade refers to receptor occupancy, not the percentage of symptoms relieved. You don't need 100% blockade for effective symptom control β most people experience substantial relief of physical symptoms (racing heart, trembling, sweating) at 70-80% blockade. Beyond ~83%, you've reached the physiological plateau where additional dose provides minimal additional effect.